Open the flight menu (plane icon on the lower toolbar) and you'll see a list of places you can send your planes to. Each flight is suited to a particular type of plane, and no other planes can do it. Furthermore, each flight requires a specific number of passengers (suitcase icon) and fuel (barrel icon), and certain flights require additional items. If you have the right plane, the right number of passengers and fuel, as well as the required items, press the Fly button. Your plane will automatically appear on the right runway. You then need to tap it several more times to fuel it, board it and signal it to take off.
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